Development of a knowledge-based economy in the absence of an innovation ecosystem that provides the foundation for the growth and development of knowledge-based and technological businesses seems impossible. Therefore, the Vice-Presidency for science and technology affairs has dedicated extensive efforts to culture-building and promoting the ecosystem of innovation and entrepreneurship in the country in the past few years. In this regard, universities are one of the major players of the innovation ecosystem, activities of which essentially affect the macro performance of the innovation system in the country

 Universities are among the major players of the innovation ecosystem, activities of which essentially affect the macro performance of the innovation system in the country.  As such, all available political tools must be exploited so that universities could properly play their role in the innovation and technology system of the country. In this context, one of the universities that have been able to take valuable steps on this path is Sharif University of Industry. Statistics show that more than 150 knowledge-based companies and businesses have been formed by students, faculty members, and graduates of Sharif University due to the efforts made by this university in the field of knowledge and technology commercialization. In addition, reports have indicated an increasing growth in this field. Therefore, the knowledge-based economy and culture-building technologies development headquarter has documented the strategies and measures of the universities and has evaluated the consequences and impacts of these acts to help Sharif University promote its experiences in the field of commercialization of scientific and technological achievements of students and faculty members and formation of sustainable and powerful knowledge-based businesses.  It is hoped that this report, which is the result of the evaluation of reports and documents related to interviews with the informed managers and experts of the university to transfer their experiences to other universities of the country.